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KMID : 0923620140140030123
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Immune Network
2014 Volume.14 No. 3 p.123 ~ p.127
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Interleukin-32 in Inflammatory Autoimmune Diseases
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Kim Soo-Hyun
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Abstract
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Interleukin-32 (IL-32) is a cytokine inducing crucial in-flammatory cytokines such as tumor necrosis factor-α (TNFα) and IL-6 and its expression is elevated in various in-flammatory autoimmune diseases, certain cancers, as well as viral infections. IL-32 gene was first cloned from activated T cells, however IL-32 expression was also found in other im-mune cells and non-immune cells. IL-32 gene was identified in most mammals except rodents. It is transcribed as multi-ple-spliced variants in the absence of a specific activity of each isoform. IL-32 has been studied mostly in clinical fields such as infection, autoimmune, cancer, vascular disease, and pulmonary diseases. It is difficult to investigate the precise role of IL-32 in vivo due to the absence of IL-32 gene in mouse. The lack of mouse IL-32 gene restricts in vivo studies and restrains further development of IL-32 research in clinical applications although IL-32 new cytokine getting a spotlight as an immune regulatory molecule processing important roles in autoimmune, infection, and cancer. In this review, we discuss the regulation and function of IL-32 in inflammatory bowel diseases and rheumatoid arthritis.
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KEYWORD
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Cytokine, Inflammatory diseases, Inflectional im-mune responses, Immune cell differentiation, Inflammatory cancer
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